| Sedicesimi di Finale |
| 18/02/202118:55 | WolfsbergLiendl M. (rigore) | 1 - 4 | TottenhamSon H., Bale G., Moura L., Vinicius M. |
| 24/02/202118:00 | TottenhamAlli D., Vinicius M., Bale G., Vinicius M. | 4 - 0 | Wolfsberg |
| 18/02/202118:55 | Dinamo KievBuyalskyi V. | 1 - 1 | Club BrugesMechele B. |
| 25/02/202121:00 | Club Bruges | 0 - 1 | Dinamo KievBuyalskyi V. |
| 18/02/202118:55 | Real Sociedad | 0 - 4 | Manchester UnitedFernandes B., Fernandes B., Rashford M., James D. |
| 25/02/202121:00 | Manchester United | 0 - 0 | Real Sociedad |
| 18/02/202121:00 | BenficaPizzi L. (rigore) | 1 - 1 | ArsenalSaka B. |
| 25/02/202118:55 | ArsenalAubameyang P., Tierney K., Aubameyang P. | 3 - 2 | BenficaGonçalves D., Silva R. |
| 18/02/202118:55 | Stella RossaKanga G. (rigore), Pavkov M. | 2 - 2 | MilanPankov R. (autogoal), Hernandez T. (rigore) |
| 25/02/202121:00 | MilanKessié F. (rigore) | 1 - 1 | Stella RossaBen Nabouhane E. |
| 18/02/202121:00 | Royal Antwerp | 3 - 4 | Glasgow Rangers |
| 25/02/202118:55 | Glasgow Rangers | 5 - 2 | Royal Antwerp |
| 18/02/202118:55 | Slavia Praga | 0 - 0 | Leicester City |
| 25/02/202121:00 | Leicester City | 0 - 2 | Slavia PragaProvod L., Sima A. |
| 18/02/202121:00 | Salisburgo | 0 - 2 | Villarreal |
| 25/02/202118:55 | Villarreal | 2 - 1 | Salisburgo |
| 18/02/202118:55 | Sporting Braga | 0 - 2 | RomaDzeko E., Mayoral B. |
| 25/02/202121:00 | RomaDzeko E., Perez C., Mayoral B. | 3 - 1 | Sporting BragaCristante B. (autogoal) |
| 18/02/202118:55 | KrasnodarBerg M., Claesson V. | 2 - 3 | Dinamo ZagabriaPetkovic B., Petkovic B., Atiemwen I. |
| 25/02/202121:00 | Dinamo ZagabriaOrsic M. | 1 - 0 | Krasnodar |
| 18/02/202118:55 | BSC Young BoysFassnacht C., Siebatcheu J., Elia M., Siebatcheu J. | 4 - 3 | Bayer 04 LeverkusenSchick P., Schick P., Diaby M. |
| 25/02/202121:00 | Bayer 04 Leverkusen | 0 - 2 | BSC Young BoysSiebatcheu J., Fassnacht C. |
| 18/02/202121:00 | Molde FKEllingsen M., Andersen E., Fofana D. | 3 - 3 | HoffenheimDabbur M., Dabbur M., Baumgartner C. |
| 25/02/202118:55 | Hoffenheim | 0 - 2 | Molde FKAndersen E., Andersen E. |
| 18/02/202121:00 | Granada | 2 - 0 | Napoli |
| 25/02/202118:55 | Napoli | 2 - 1 | Granada |
| 18/02/202121:00 | Maccabi Tel Aviv | 0 - 2 | Shakhtar DonetskPatrick A., Tete M. |
| 25/02/202118:55 | Shakhtar Donetsk | 1 - 0 | Maccabi Tel Aviv |
| 18/02/202121:00 | LOSC LilleWeah T. | 1 - 2 | AjaxTadic D. (rigore), Brobbey B. |
| 25/02/202118:55 | AjaxKlaassen D., Neres D. | 2 - 1 | LOSC LilleYazici Y. (rigore) |
| 18/02/202118:55 | OlympiacosBouchalakis A., M'vila Y., El Arabi Y., Masouras G. | 4 - 2 | PSV EindhovenZahavi E., Zahavi E. |
| 25/02/202121:00 | PSV EindhovenZahavi E., Zahavi E. | 2 - 1 | OlympiacosHassan A. |
